Contraindicated (one)pentobarbital will reduce the extent or effect of cariprazine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. CYP3A4 is to blame for the formation and elimination of cariprazine's Lively metabolites.pentobarbital will decrease the level or impact of disopyramide by influencing hepatic/intestinal enzym… Read More